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PI3K/Akt Modulates Adipogenesis [69] Activation of PI3K/Akt: Supports normal activities of the fat cells Stops the changes in the functioning of adipocytes that occur during obesity Result: Even adipogenesis Less pathological fat deposits 4

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Chakraborty R, Hampton OA, Shen X, Simko SJ, Shih A, Abhyankar H, Lim KP, Covington KR, Trevino L, Dewal N, Muzny DM, Doddapaneni H, Hu J, Wang L , Lupo PJ, Hicks MJ, Bonilla DL, Dwyer KC, Berres ML, Poulikakos PI, Merad M, McClain KL, Wheeler DA, Allen CE, Parsons DW

Environmental exposure to PCBs has been associated with an increased risk of breast cancer, 50 adverse reproductive outcomes, 51 delayed neurodevelopment, 52 impairment of the immune system 53 and metabolic disruptions