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Inhibition of AKT-signaling sensitizes soft tissue sarcomas (STS) and gastrointestinal stromal tumors (GIST) to doxorubicin via targeting of homology-mediated DNA repair

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Kynurenine (Kyn), primarily produced by fibroblasts, activates AhR, induces PTEN expression, and suppresses AKT/mTOR signaling, thereby reducing fibroblast migration and activation [117]

Tesamorelin is a particularly interesting part of the peptide revolution since it is actually an FDA approved drug made by Theratechnologies, and yet it is sold OTC as a research chemical by numerous peptide brands