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10.1146/annurev-nutr-071812-161246 Annu Rev Nutr

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When this ratio shifts, it is often a sign that the body is working harder to manage oxidative stress

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CRF activation in the amygdala has also been found to be involved in reinstatement of methamphetamine seeking in response to stress in animal models [49]

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Its underlying mechanisms are multifaceted, encompassing genetic variations, environmental influences, cerebral artery constriction, abnormalities in monoamine neurotransmitters, oxidative stress, mitochondrial disturbances, the involvement of calcitonin gene-related peptide (CGRP), neurogenic inflammation, and broader neuroinflammation (6)

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