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wherein D424 is substituted with either an A, C, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y

It may reduce the absorption of oral medications by interacting with intestinal transporters, potentially affecting the bioavailability of drugs like metformin

[72] It remains to be investigated whether continuing treatment beyond the end of radiotherapy or use of a higher dose would improve these results

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4-( N -( S -glutathionylacetyl)amino)phenylarsonous acid is a prospective cancer drug and has just completed a phase I dose escalation study in patients with solid tumors refractory to standard therapy (Horsley et al., 2013)

This is supported at least in part at the biochemical level: the Km of L-cysteinyl-tRNA synthetase towards cysteine, which directs cysteine to translational machinery, is less than one tenth of that for other enzymes of cysteine metabolism such as GCS or cysteine dioxygenase 22