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AOD 9604 is a synthetic peptide fragment derived from the C-terminus of human growth hormone (HGH)

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It activates several overlapping pathways, notably VEGFR2 and nitric oxide synthesis via the Akt-eNOS axis, promoting angiogenesis, fibroblast activity, and neuromuscular stabilization

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albicans exhibits remarkable intraspecific strain heterogeneity, which is driven by genetic variations including aneuploidy, loss of heterozygosity, copy number variations and single nucleotide polymorphisms, as well as epigenetic phenotypic switching and niche-specific adaptive regulation, and this heterogeneity directly leads to significant differences in pathogenicity, biofilm formation ability and drug responsiveness among different strains (Hirakawa et al., 2015)

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