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Reduced Inflammation and Pain MSM is renowned for its anti-inflammatory properties, and when paired with vitamin C, those effects can be amplified, leading to greater relief from inflammation-related pain

425,426 Additionally, IgG, IgM, and IgA autoantibodies against HSP60, HSP70, and HSP90 are significantly elevated in RA patients

Where does the available human evidence sit on the study design hierarchy: case report (low grade), retrospective series, or controlled trial (higher grade)

This process then potentially leads to increased sensitivity to nociceptive stimuli mediated by insula activation (Uddin, 2015)

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