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We propose a predisposition to tissue fragility in patients with clEDS, in particular of the gastrointestinal tract and emphasize the importance of counseling with regard to the risk of gastrointestinal complications

Eur J Pharmacol 771:211219 Luetic K, Sucic M, Vlainic J et al (2017) Cyclophosphamide induced stomach and duodenal lesions as a NO-system disturbance in rats: l-NAME, l-arginine, stable gastric pentadecapeptide BPC 157

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Beyond this direct scavenging role, quercetin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, a key regulator of intrinsic antioxidant defenses