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Carnosine exerts its effects by reducing zinc and copper influx near GABA receptors, thereby indirectly enhancing GABA function, particularly in the frontal cortex (182)

Replicative endothelial cell senescence may lead to endothelial dysfunction by increasing the BH2/BH4 ratio induced by oxidative stress, reducing Bh4 availability, and decreasing the expression of eNOS

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Caffeine and green tea extract produce mild metabolism effects compared to prescription medications

With respect to the crosstalk between mitochondria and the endoplasmic reticulum (ER), they reported that mitochondria-associated ER membrane (MAM) disruption and mitochondrial Zn 2+ overload in senescent NPCs subjected to oxidative stress