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The antinociception of both corynoxine and morphine was also reversed by naltrexone (0.1 mg/kg, i.v.), suggesting that the compounds act as -opioid receptor agonists

Mrquez L, Martn MV, Larson M, Almansa E (2023) Application of the thermal time model of embryonic development duration to the culture of octopod cephalopods

This was paralleled by an induction of morphine-like CB 1 receptor alterations in mitragynine-sensitized mice, reaffirming the likelihood of common hijacking of the related brain pathways