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Step 2 tert-butyl 4-(6-bromopyridin-3-yl-2,4,5-d 3 )piperazine-l-carboxylate Step 3 tert-Butyl 4-(6-((7-cyclopentyI-6-(dimethylcarbainoyI)-7H-pyrrolof2,3- d]pyrimidin-2-y l)amino)pyridin-3-yl-2,4,5-d iperazine- 1 -carboxylate 6- carboxamide 120 mg, 0.44 mmol Pd(dba) 2 (12.6 mg, 0.022 mmol) BINAP 20 mg, 0.032 mmol CS2CO3 420 mg, 1.29 mmol the reaction mixture is partitioned between dichloromethane and saturated NaHCOj solution

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