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Nature Nano

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In the second half-reaction, a sulfite molecule attacks the terminal sulfur atom of this persulfide, yielding thiosulfate and regenerating free Cys248 at the active site (Figure 13) ( k cat / K m value for the TST-catalyzed reaction with GSSH as a sulfur donor and sulfite as a sulfur acceptor was nearly 1,000-fold higher than that for the reverse reaction with thiosulfate as a sulfur donor and GSH as a sulfur acceptor ( FIGURE 13 To date, no selective small-molecule inhibitor of TST suitable for mechanistic analysis in cells or tissues has been reported

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OFarrell PH (1975) High resolution two-dimensional electrophoresis of proteins

It is unclear if the team would want a full-on overhaul at the position, but Taylor is tied to a $6MM base salary for 2025