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Discordance Between Endocrine and Paracrine/Autocrine IGF-I An important example of metabolic and mitogenic consequences of an unbalanced endocrine versus autocrine/paracrine insulin-GH-IGF-axis comes from observations in children and adolescents with type 1 diabetes (Figure 5)

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The response to GHRP2 in adults also suggests that rapid recrudescence of GHRH neuronal elements may be evoked by the ghrelin analog

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9 Kaidbey KH, Agin PP, Sayre RM, Kligman AM