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The metabolites and the pathways to which they belong have been grouped into five groups viz.-(i) Central Carbon metabolism (glce, glcc, g6p, f6p, f16bp, gap, dhap, 1,3bpg, 3pg, akg), (ii) Amino Acid metabolism (3php, pser, ser, gly, cyse, cys, cysL, glute, glut), (iii) Thiol metabolism (glucys, gsh, gssg), (iv) h2o2 production and metabolism (O2(ex), O2, oxrad, h2o2) (v) Redox metabolism (nadph, nadp+)

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The proportion of these cells correlated with the severity of SLE flares.86 EWAS in SLE Key points The most robust finding from EWAS is the hypomethylation of interferon-responsive genes in patients with SLE compared to healthy controls

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