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As the phospho-HSL level in the transplanted fat pad was similar to that of endogenous WAT in WT/HFD mice (Fig

But nothing seemed to help

The 2015 paper reported that MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance (PMID 25738459)

A modified peptide fragment designed to stimulate lipolysis, the breakdown of stored fat, without affecting blood sugar or growth hormone levels

(III.2.F) EXVIVO STUDY Ex vivo study on goat sublingual mucosa shows increase in permeation of drug through mucosa than that of In vitro condition because chitosan is able to break tight junction hence facilitate the passage of drug through this route .On the other hand PG will increase the pore size of the membrane along with alcohol as a result increase in Para-cellular movement of the drug .Therefore Ex- vivo data will help to predict In- vivo permeation pattern of the formulation

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