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Every animal was recorded and tracking was performed using Ethovision software (Noldus, Wageningen, the Netherlands)

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Interestingly, TAF1 heterozygous KO female mice display no overt brain abnormalities but show significantly increased weight with age and reduced movement, suggesting that specific neuronal populations are adversely affected by TAF1 deletion

Patients who received the combination as second-line treatment to supportive therapy were included in Group 4 at first and Group 1 later on