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Although this view was later attenuated based on the head-to-head conformation of the DNA-bound DBD dimer that was observed in X-ray crystallography studies and observations of relaxed response element stringency for selective chromatin binding [51, 52], it did point to the potential of variability in the composition of AREs and to deviations from the ideal 15 bp sequence

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Conclusions ROSs play an essential role in the autophagy-associated apoptosis in PFOS-treated RTCs, which is associated with the impairment of mitochondrial bioenergetics and the effects of uncoupling on reduced ATP synthesis

After removal of duplicates, 329 citations remained, of which 118 were considered for full-text review