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Methods/design Study design This clinical trial will use a double-blind, placebo-controlled, dose escalation design, with random assignment of participants to an experimental (group A) and a control condition (group B) for 10 weeks after failure to achieve abstinence during an open-label run-in period of approximately 2 weeks using a 21-mg nicotine patch daily

As CS co-exposure attenuated AHR in both model systems, we could not determine the impact of standard asthma therapies on this end point

The name comes from the tobacco company founded in 1873 called Liggett & Myers, predecessor of Liggett Group, by whom L&M was originally produced

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