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They also widely affect nonhistone proteins, influencing biological processes, including DNA repair, the cell cycle, and drug resistance

In microglia, TREM2 is responsible for synaptic inhibition and establishing normal brain connections, maintaining innate immune homeostasis and cellular metabolism (186)

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(2012) identified four subtypes of adenomyosis, defined as due to direct endometrial invasion (Subtype I), endometriotic invasion from the outer uterus (Subtype II), de novo metaplasia (Subtype III) and heterogeneous, advanced disease of mixed phenotype (Subtype IV)