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Hes1 and Hey1, known as direct downstream targets of Notch, belong to an extensive family of basic helix-loop-helix (bHLH) proteins and play a critical role in the regulation of cell cycle and apoptosis in various cancers [52, 53]

10.1186/s12864-018-5160-5 81 LalauJ

doi: 10.1016/j.biopha.2022.113810 58 MacchioneI

They hypothesized that cysteine deprivation impairs the ETC activity and Krebs cycle, leading to hyperpolarization of the IMM followed by lipid peroxidation [230]

Hum Psychopharmacol 21(6):355366

Therefore, this combination treatment system effectively inhibits tumor growth through the synergistic effects of exo- and endogenous ferroptosis and immune microenvironment regulation