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By use of cultured immortalized podocytes and mouse models, they could demonstrate that GH excess activates Notch1 signaling in podocytes resulting in podocyte loss

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Verschillende factoren zoals veroudering, stress, een onevenwichtig dieet, vervuiling en bepaalde ziekten kunnen echter de glutathionspiegels in het lichaam verlagen, waardoor het vermogen van het lichaam om cellen te beschermen en toxines te elimineren, wordt verminderd