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Of note, mice lacking insulin receptors in cardiomyocytes (CIRKO mice) also showed impaired ATP/O ratios when respiring palmitoyl-carnitine, which was normalized by scavenging mitochondrial ROS using manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), thereby not only confirming that ROS may induce uncoupling but also suggesting a critical role of cardiac insulin resistance in the pathogenesis of ROS-induced mitochondrial uncoupling [35]

Controlled in-cell activation of RNA therapeutics using bond-cleaving bio-orthogonal chemistry

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Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice

2021, Dec;161:105557

These substitutes exhibit comparable or enhanced endocrine-disrupting potential relative to BPA (232)