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(3) The observed decrease in carnitine and CPT I expression in cardiac tissues by SUN was parallel to the increase in cardiac index, cardiac enzymes and myocardial fibrosis which may point to the possible contribution of carnitine deficiency and the inhibition of CPT I as possible mechanisms in SUN-induced cardiotoxicity

37,38 Other than lipid accumulation in kidney tissues, CKD patients always have dyslipidemia, which is characterized by high levels of serum triglycerides, LDL-cholesterol (LDL-C), and low HDL-cholesterol (HDL-C) levels

Trimethylamine and trimethylamine N-Oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease

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Although patients on pregabalin therapy showed an earlier onset of therapeutic effect as compared to oxcarbazepine, the efficacy of the two drugs was found comparable during the 12 weeks of the follow-up period of the study [48]

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