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Many natural drugs can regulate the cell cycle and promote apoptosis in FLSs through the mitochondrial pathway (263, 264)

Abbreviations 5-FU: 5-Fluorouracil 15d-PGJ2: 15-Deoxy-delta 12,14-prostaglandin J2 A1AT: Alpha-1 antitrypsin ABCA1: ATP-binding cassette transporter A1 ABCG1: ATP-binding cassette subfamily G member 1 AF: Atrial fibrillation AGEs: Advanced glycation end-products AI: Artificial intelligence AKR1B1: Aldo-keto reductase family 1 member B1 Akt: Protein kinase B ALA: Alpha-linolenic acid ALT: Alanine aminotransferase AMH: Anti-Mllerian hormone AMPK: AMP-activated protein kinase ANGPTL4: Angiopoietin-like protein 4 AP-1: Activator protein 1 ARB: Angiotensin receptor blocker AS-IV: Astragaloside IV AST: Aspartate aminotransferase AT: Adipose tissue ATP: Adenosine triphosphate BAT: Brown adipose tissue BBB: Blood-brain barrier Bcl-2: B-cell lymphoma 2 BMD: Bone mineral density BMI: Body mass index BSO: Black seed oil BNP: B-type natriuretic peptide BVC: Bavachinin CAD: Coronary artery disease CAFs: Cancer-associated fibroblasts CAP: Controlled attenuation parameter Cav-1: Caveolin-1 CB1: Cannabinoid receptor 1 CDK-4: Cyclin-dependent kinase 4

van der Jagt, D.L., Hunsaker, L.A., Garcia, K.B

Oxygen: The Molecule that Made the World

Therefore, it was indicated that ROS increased by treating eprenetapopt, and the ROS induced apoptosis

doi: 10.1186/s40538-021-00212-z 71