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Additionally, in cell culture experiments, NAC protected against H3N2 influenza virus-induced oxidative stress, cell death, the expression of inflammatory genes, and NF-B activity [62,63]

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

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Structurally, it is the only GPX isoform with a monomeric conformation and a unique catalytic tetrad including Sec, Gln81, Trp136, and Asn137 that enables it to reduce complex hydroperoxides in situ even within membranes ( Transcriptionally, GPX4 expression is promoted by Nrf2 and ATF4 in response to oxidative or endoplasmic reticulum stress