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Indeed, although several strategies have been devised to circumvent CDDP resistance in cancer patients, including (but not limited to) the use of CDDP in combination with targeted anticancer agents such as erlotinib (a pharmacological inhibitor of the tyrosine kinase activity of EGFR), trastuzumab (an EGFR-specific antibody) and bevacizumab (a vascular endothelial growth factor-blocking antibody), a majority of these combinatorial regimens failed to improve the therapeutic profile of CDDP in randomized clinical trials

Glutathione in metastases: From mechanisms to clinical applications

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We used standard peptides to create a dilution series for generating a standard curve

Microbial production of isoflavonoids had been difficult because isoflavone synthase, a key enzyme catalyzing the production of isoflavonoids from naringenin, is a membrane-bound cytochrome P450 enzyme that requires a specific electron transfer system