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In the present study, we investigated the central effects of growth hormone (GH) on energy homeostasis as GH fulfills several requisites of an energy-deficiency signal to the brain

21 The top 10% of proteins within these networks were scored for network topology (connectivity and bottleneck) and used as markers of essential pathway functions, 22, 23 which were identified using the Reactome algorithm 24 plug-in for Cytoscape 2.8.2 25 (Supplementary Figure S2)

Negative Effects 1) Acromegaly The hypersecretion of GH (mostly due to benign tumors in the pituitary gland) results in a condition called acromegaly

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