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Cheminformatic analysis to quantify the divergence between our reported peptide sequences and known streptavidin binders To understand and evaluate the chemical diversity and dissimilarity between CCA cyclized peptides (Str1-9, sequences obtained from L1-CCA library selection) and linear peptides exhibiting the HPQ pattern (HPQ1-12, sequences obtained from L1-Lin library selection), we employed chemoinformatic analysis using three distinct methods

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