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The weight loss achieved by CagriSema (-20.4% at 68 weeks) is comparable to that reported with the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist tirzepatide (-20.9% with the 15-mg dose at 72 weeks in SURMOUNT-1) [14]

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Potential Benefits Works through amylin receptors rather than GLP-1, offering an alternative pathway for patients who may not respond optimally to GLP-1 medications alone

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Nausea typically peaks in weeks 26 and lessens by week 810 at steady-state dosing as receptor sensitivity downregulates