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All the animal experiments were approved by the Animal Ethics Committee of Second Affiliated Hospital of Army Medical University (AMUWEC20224530) and performed in accordance with the NIH Guide for the Care and Use of Laboratory Animals (National Academies Press, 2011)

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Osteochondroprogenitor-specific deletion of Trsp gene significantly impaired chondrogenic programs, causing abnormalities in bone and cartilage development in mice 73

This blend has drawn growing research interest in studies focused on how overlapping peptide systems interact across extracellular, barrier-associated, and structurally active tissue environments

For example, when histamine binds to a receptor on endothelial (blood vessel) cells, it causes vascular permeability, resulting in swelling and inflammation