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The study showed mechanistically that mtDNA released into the cytosol can bind to NLRP3, triggering its activation and the subsequent production of inflammatory cytokines like IL-1, contributing to inflammation in lung tissues (Nakahira et al., 2015) (Figure 2)

ATP and adenosine: role in the immunopathogenesis of rheumatoid arthritis

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(1A) CVD risk in patients with MAFLD should be assessed using the China atherosclerotic CVD (ASCVD) risk chart, supplemented by additional testing such as 24-h electrocardiogram, heart rate variability, and carotid plaque assessment when indicated

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