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These neoplasms can be very aggressive but as they are lacking angiogenesis, it was immediately evident that anti-angiogenic treatment could have been completely ineffective in these patients and, for the first time, was suggested that this type of therapeutic approach could face resistance, as all the others do [5]

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This article was submitted to Predictive Toxicology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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