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Finally, systemic metabolic conditions such as diabetes, aging, and obesity introduce additional complexity by altering baseline oxidative tone, mitochondrial resilience, and inflammatory sensitivity

Postharvest Biol Technol 95:6469

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Somewhat surprisingly HDFA by itself does not appear to have a major significant effect on redox regulation or methylation pathways possibly because children were not pre-screened for low baseline GSH/GSSG