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In mice, shed IECs have been shown to persist for several hours, promoting the expression of antimicrobial genes at the tips of villi and helping to control the makeup of the gut microbiota (219).The rate of senescent epithelial monolayer cell clearance and the growth of stem cells in the crypts are both correlated with the shedding and renewal of IECs (220, 221)

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show that pure WA or WS extract containing WA totally reduced (NFB) activation caused by inflammatory agents regardless of the type of cell, but not AP1 activity [116]