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Cauda equina syndrome is the most serious emergency - if you experience loss of bladder or bowel control, numbness in your groin area, or severe weakness in both legs, you need emergency care immediately

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242 PKC activation enhances excitatory currents in the dorsal horn and trigeminal neurons, contributing to nociceptive hypersensitivity in DPN

4,25 The prevalence of DPN is significantly higher in developing countries, often exceeding 50% among diabetes patients