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Professor John Cooke from Houston, also known as a pioneer in arginine research, even described arteriosclerosis as a kind of 'arginine deficiency disease'

doi: 10.1007/s002130051142

Downregulation/knockout of the autophagy apparatus such as Atg5, Atg3 (autophagy-related-5 and 3), Beclin 1 and LC3 (Microtubule-associated protein 1A/1B-light-chain-3) lead to impaired autophagy, and incomplete mitochondrial beta-oxidation resulting in the accumulation of hepatic triglycerides and toxic lipid intermediates, causing mitochondria-induced apoptosis (Hammad et al., 2023[54]

NAPstars are thus self-contained probes and unlike iNap sensors, they do not rely on probe dimerisation to function 15

Receptor binding redefined by a structural switch in a mutant human insulin

Chan et al.,2004 Chan FK, Hung LC, Suen BY, Wong VW, Hui AJ, Wu JC, Leung WK, Lee YT, To KF, Chung SC, Sung JJ.(2004) Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial Gastroenterology 127(4):1038-43