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LebedevAVNilssonJLindstrmJFredborgWAkenineUHillilCet al

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Chronic illness, inadequate nutrition, alcohol use, smoking, and prolonged stress may also reduce levels

DSF/Cu dramatically activates the phosphorylation of p62, which facilitates competitive binding to Keap1 for degradation, thereby prolonging the half-life of Nrf2 (Jiang et al., 2014)