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S2: glutathione binding pocket, S3: spermidine binding region, S3+S4: N8-glutathionylspermidine binding pocket

This mechanism involves cycling between two conformational states, the matrixopen state or mstate in which the substrate binding site is open to the mitochondrial matrix, and the cytoplasmicopen state or cstate where it is open to the intermembrane space [71, 72, 76, 77] (Figure 2C)

In summary, DUSP6 may contribute to the pathogenesis of arthritis by inhibiting IL-10 production in mice

Abstract Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment

Targeted metabolomics approach for identification of relapsingremitting multiple sclerosis markers and evaluation of diagnostic models

Notably, bile salts and vitamin B12 are absorbed in the terminal ileum