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183 In addition, Small molecule antagonists which inhibit TGF- receptor kinase or TGF- activated pathways were studied, 184,185 although the long-term safety of such drugs might be a problem, particularly as TGF- affects tissue repair and is a potent anti-inflammatory mediator (Table 3)

[DOI] [PMC free article] [PubMed] 38.Bonomini M., Pandolfi A., Di Liberato L., Di Silvestre S., Cnops Y., Di Tomo P., D'Arezzo M., Monaco M.P., Giardinelli A., Di Pietro N., et al

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The liver stores B12, and these stores can last a significant time (up to several years for non-deficient individuals), but when they are depleted, it takes consistent input to rebuild and maintain them