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A genetic variant in CAMKK2 gene is possibly associated with increased risk of bipolar disorder

Patients with Alzheimers disease have increased cellular amyloid uptake

Similar adaptive mechanisms have been observed in other neurological conditions, where reduced EAAT2 levels in certain brain regions appear to help maintain E/I balance (O'Donovan et al., 2017

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Iron overload can produce autophagic death and ferroptosis, and promote the phosphorylation of tau protein to form nerve fiber tangles, increasing the risk of TBI patients suffering from neurodegenerative diseases such as Alzheimers disease and Parkinsons disease