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To test this hypothesis, we stably knocked down the expression of LRRC8A, the mandatory subunit of VRAC channels 10 , in THP-1 cells by using a lentiviral-based shRNA strategy, silencing LRRC8A expression by more than 80% as compared with parental control cells (Fig

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NADPH Oxidase Dysregulation of multiple transmembrane NOX proteins are implicated in ALS (Bedard and Krause, 2014)