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Furthermore, PCoA showed a clear separation between the fecal microbiota profiles of model and wild-type mice, suggesting that APP/PS1 mice harbor distinct microbial communities compared to their wild-type counterparts (Supplementary Figure 3)

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Studies have indicated that the overexpression of SNRPD1 may promote cancer cell proliferation and survival by regulating key biological processes such as RNA splicing, cell cycle progression, and DNA replication

Acknowledgements This work was supported by the US National Institutes of Health (NIH) grant (R35 CA197588), Stand Up to CancerAmerican Association for Cancer Research grant (SU2C-AACR-DT22-17), and the Damon Runyon Cancer Research Foundation

Basal extracellular GSH and SCN levels in the CFTR (-) cell lines were roughly half of the CFTR (+) cell line