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While these clusters are predictive of disease activity, treatment requirements, complications, and mortality, it also points to autoantibodies as being a fundamental underlying mechanism of immune dysregulation and disease pathogenesis of SLE

In healthy individuals, the intestinal barrier prevents LPS from entering the circulation

Hepatic porphyrias are transmitted as an autosomal dominant trait

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Additional neurologic findings such as developmental delay, seizures, hypotonia with or without neuromuscular disease manifestations, cognitive impairment, myopathy, and cranial nerve dysfunction have been reported in up to 29% of CVS patients allowing to propose a subtype called CVS plus (85)

Plant Physiol Biochem 199:107727