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Current pharmacological interventions primarily target acetylcholine deficiency and amyloid plaque formation, but offer limited efficacy and are often associated with adverse effects

In adipocytes, NNMT inhibition elevates NAD and SAM and suppresses de novo lipogenesis in a concentration-dependent manner, consistent with on-target activity [13]

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Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes

USA 106 , 50885092 (2009)