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Ethical Statement Animal experiments were carried out in accordance with the European Communities Council Directive of November 24, 1986 (86/609/EEC), revised in 2010 (2010/63/EU), regarding care of laboratory animals in an AAALAC-accredited facility following acceptance of the study design by the Institute of Lab Animal Science (Chinese Academy of Science, Beijing, China) IACUC for experiments conducted on non-human primates

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elegans upon adh-5(RNAi) We used the strain JV1, unc-119(ed3) ;jr Is1 [ rpl-17 p::HyPer + unc-119 (+)] to image the induction of H 2 O 2 30 , and the strain CL2166, dv Is19 [(pAF15) gst-4 p::GFP::NLS] 63 for oxidative stress signalling induction

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