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It would certainly be preferable that GSHee be delivered in a dose form that would not elicit profound responses prior to administration of an opioid and we are establishing whether lower doses or a constant infusion can achieve blockade of fentanyl-induced OIRD without eliciting dramatic effects on ventilation prior to administration of the opioid

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The participant was able to complete the required calibration trials and the 100 training trials per session for all 10 sessions and post-training demonstrated increased ankle dorsiflexion velocity, walking speed and step length

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A 2000 study by Simeon et al