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elegans , included three targeting genes encoding peroxide-detoxifying enzymes: two catalases ( ctl-1 and ctl-2 ) and the mitochondrial 2-Cys peroxiredoxin ( prdx-3 )

Cancer Certain GST variants have been associated with an increased risk of cancer development due to their potential impairment of detoxification processes for carcinogens and reactive oxygen species, thereby promoting DNA damage and oncogenesis

There is evidence that these cytokines do not cross the healthy blood-brain barrier and they are rapidly broken down after release but passage between the CNS and blood still remains a possibility (Steensberg et al., 2006