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Thyroid dysfunction, particularly hypothyroidism, often leads to fatigue, and B12 can help combat this by boosting energy levels

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Together they form a heterotetrameric complex that is internalized into early endosomes, where the heterotetrameric receptor complex can phosphorylate Mothers against decapentaplegic homolog 2 (SMAD2) and/or SMAD3 proteins [12, 14, 15]