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Precautions apply for patients with known allergies, asthma history, pregnancy, lactation, or significant underlying illness, based on local medical guidance

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Certain tumors escape ferroptosis by upregulating system xc (a cystine/glutamate antiporter composed of SLC7A11 and SLC3A2) or glutathione peroxidase 4 (GPX4), a key enzyme that reduces lipid hydroperoxides and protects cells from ferroptotic death [1]

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Studies have demonstrated that siRNA-mediated inhibition of the p47(phox) and p22(phox) subunits of NADPH oxidase not only prevents its activation but also reduces miR-21 expression

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