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Furthermore, these compounds reduce serum proinflammatory cytokines, including Tumor Necrosis Factor-alpha (TNF-), Interleukin-1 beta (IL-1), and IL-6, while modulating apoptosis by downregulating BAX and upregulating Bcl-2, preventing caspase-3 activation

Xiao serve on the Scientific Advisory Board of the Open Medicine Foundation, a non-profit charity that supports collaborative medical research for ME/CFS and other complex chronic diseases

Studies show 23 that creatine supplementation can increase the activity of osteoblasts (cells involved in the bone formation process) and reduce bone resorption (bone loss)