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Sirtuins also perform other post-translational reactions such as NAD + -dependent desuccinylation, diacylation, and demalonylation, and are important in regulating metabolism, allowing metabolic plasticity 7

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For example, some people lack a protein called intrinsic factor , which helps with the absorption of vitamin B12

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CD38 inhibition, resulting in increased NAD + levels, may slow aspects of the aging trajectory and enhance immune function, making it a promising area of research for various diseases 137,138